2012年3月23日，在本月《细胞》（Cell）前十名下载论文中，华大基因的两项单细胞测序研究成果分别名列第二和第七，成为本月最受关注的十篇文章之一。《细胞》杂志创刊于1976年，以发表具有重要意义的原创性科研报告为主，现已成为世界自然科学研究领域最著名的期刊之一，并陆续发行了十几种姊妹刊，在各自专业领域里均占据着举足轻重的地位。
3月2日，华大基因在肿瘤研究上获得突破性进展，于《细胞》杂志同期在线发表两篇研究论文。这两项研究成果首次应用单个癌细胞全外显子测序的方法对血液癌症和固体肾脏肿瘤展开研究，为从单核苷酸水平深入研究癌症发生、发展机制及其诊断、治疗提供了新的研究思路并开辟了新的研究方向。
本月《Cell》杂志前十名下载论文为：
1 Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes
Rui Chen, George I. Mias, Jennifer Li-Pook-Than, Lihua Jiang, Hugo Y.K. Lam, Rong Chen, Elana Miriami, Konrad J. Karczewski, Manoj Hariharan, Frederick E. Dewey et al.
2 Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm
Yong Hou, Luting Song, Ping Zhu, Bo Zhang, Ye Tao, Xun Xu, Fuqiang Li, Kui Wu, Jie Liang, Di Shao et al.
3 Hallmarks of Cancer: The Next Generation
Douglas Hanahan, Robert A. Weinberg
4 Mechanisms for Insulin Resistance: Common Threads and Missing Links
Varman T. Samuel, Gerald I. Shulman
5 Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD
Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes et al.
6 Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer
Elizabeth P. Murchison, Ole B. Schulz-Trieglaff, Zemin Ning, Ludmil B. Alexandrov, Markus J. Bauer, Beiyuan Fu, Matthew Hims, Zhihao Ding, Sergii Ivakhno, Caitlin Stewart et al.
7 Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor
Xun Xu, Yong Hou, Xuyang Yin, Li Bao, Aifa Tang, Luting Song, Fuqiang Li, Shirley Tsang, Kui Wu, Hanjie Wu et al.
8 Antibody-Based Immunotherapy of Cancer
Louis M. Weiner, Joseph C. Murray, Casey W. Shuptrine
9 Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model
Jennifer S. Pfingsten, Karen J. Goodrich, Cornelius Taabazuing, Faissal Ouenzar, Pascal Chartrand, Thomas R. Cech
10 Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
Ralph J. DeBerardinis, Craig B. Thompson
相关链接：
华大基因单细胞测序成果登Cell研究新亮点，引领癌症研究新时代